Recent Hearing Restoration Project Papers

Groves and Segil Labs

Iyer AA, Hosamani I, Nguyen JD, et al. Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals. eLife. 2022;11:e79712. doi:10.7554/eLife.79712
Tao L, Yu HV, Llamas J, et al. Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration. Developmental Cell. 2021;56(17):2471-2485. doi:10.1016/j.devcel.2021.07.003

Janesick A, Scheibinger M, Benkafadar N, Kirti S, Heller S. Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells. Development. 2022;149(8):dev.200113. doi:10.1242/dev.200113
Janesick A, Scheibinger M, Heller S. Molecular Tools to Study Regeneration of the Avian Cochlea and Utricle. In: Groves AK, ed. Developmental, Physiological, and Functional Neurobiology of the Inner Ear. Neuromethods. Springer US; 2022:77-97. doi:10.1007/978-1-0716-2022-9_5
Scheibinger M, Janesick A, Benkafadar N, Ellwanger DC, Jan TA, Heller S. Cell-type identity of the avian utricle. Cell Reports. 2022;40(13). doi:10.1016/j.celrep.2022.111432
Scheibinger M, Janesick A, Diaz GH, Heller S. Immunohistochemistry and In Situ mRNA Detection Using Inner Ear Vibratome Sections. In: Groves AK, ed. Developmental, Physiological, and Functional Neurobiology of the Inner Ear. Neuromethods. Springer US; 2022:41-58. doi:10.1007/978-1-0716-2022-9_3

Ament SA, Adkins RS, Carter R, et al. The Neuroscience Multi-Omic Archive: a BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain. Nucleic Acids Res. 2023;51(D1):D1075-D1085. doi:10.1093/nar/gkac962