David Ehrlich, Ph.D
Meet the Researcher
Ehrlich received his doctorate in neuroscience from Emory University in Atlanta, and was a neuroscience research fellow at the Hospital for Sick Children in Toronto. He is a postdoctoral fellow in the department of otolaryngology–head and neck surgery and the Neuroscience Institute at the New York University School of Medicine. Ehrlich’s 2018 grant was partially funded by the Meringoff Family Foundation in New York City.
Loss of balance and consequent, harmful falls are common in aging populations and associated with various neurological disorders. Balance is sensed using vestibular organs in the inner ear and is processed in the brainstem, the first brain center for processing sensations of both hearing and balance. This project aims to uncover how the brain transforms sensations of instability into corrective movements to restore balance.
My strategy is to leverage the relative simplicity of balance reflexes to define how brainstem cells represent information both individually and collectively. In order to measure balance responses in populations of cells located deep within the brain, I apply cutting-edge microscopy techniques to a transparent animal, the zebrafish. These fish must swim to restore balance when pushed away from the horizontal, providing a tractable model for balance control and brainstem function in general.
When we look at fish from the side, they behave more like humans. Just as we tilt away from an upright stance in order to walk, dance, or play sports, fish tilt up and down to swim agilely. This insight makes fish a simple model to study how sensations of balance are integrated into the brain to perform stable yet effective movements.
Enamored of buildings and other human-made structures, as a young child I wanted to be an architect. I now like to think of myself as a student of the naturally intricate structures of the brainstem. I am also a great fan of playing percussion in a number of genres: jazz, rock, hip-hop. Some of my earliest inspiration for studying the brain came from a fascination with how music can change one’s mood.
My younger brother Max and I collaborated to design a board game. Players make up definitions for acronyms to impress their friends and family. Perhaps some inspiration came from the many acronyms used in research! We hope to eventually produce and distribute the game.
Eventually I hope to oversee a research laboratory as a professor of neuroscience. The work supported by my Emerging Research Grant is laying the technical and conceptual groundwork for studying how cells distributed throughout the zebrafish brain process sensations from the inner ear, eventually informing therapeutic strategies to treat balance deficits.
David Ehrlich, Ph.D.’s grant is partially supported by the Meringoff Family Foundation, a New York City–based organization whose mission is to improve the lives of local children through support of education, research, and public health.
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The Research
New York University School of Medicine
Neural computations for vestibular control of movement initiation
Loss of balance and falls are common in aging populations and associated with various neurological disorders. Balance is sensed using vestibular organs in the inner ear and processed in the brainstem. However, it remains unclear how the brainstem transforms sensations of instability into corrective movements that restore balance. The objective of this project is to define how cells in the brainstem act collectively to produce rapid responses to sensations of instability. In order to measure balance responses in populations of cells located deep within the brain, this project will apply cutting-edge microscopy techniques to the zebrafish. These fish swim to remain balanced, providing a model for balance control and brainstem function in general.
Long-term goal: To reveal general principles of how brain cells encode sensations from the inner ear and how the brain initiates responses when stability is lost, in order to inform therapeutic strategies to treat balance deficits.